Did you know that our bodies are made up of more than 100 billion cells?! Changes in just one of these cells can eventually lead to something called cancer. Let's find out more below.
Our cells have a nucleus that contains our chromosomes which are formed of our genes. These genes are really important in controlling the cell. They tell the cell what jobs to do, what type of cells to form, when to divide and when to die. Our genes are really important in controlling cell division and making sure they don't grow out of control. Sometimes our genes get corrupted, we call this a mutation. Mutations are random and might cause our cells to divide rapidly and form a tumour. Some mutations don't have any effect at all on our cells.
There are two types of tumour, benign and malignant:
Benign tumours are a group of cells that are normally contained in one area by a cell membrane. These cells grow very slowly and don't invade other body parts. Because they are contained in an area they can be easily removed. Benign tumours can be life-threatening especially if they are found in or near major organs and interrupt with normal organ functions.
Malignant tumour cells can spread around the body, invading neighbouring healthy tissues. Cells from malignant tumours might break up and enter the blood or lymphatic system. They can then lodge into another organ and form a secondary tumour. These cells divide faster than benign tumour cells, disrupting the organs function which can lead to death.
How come some people get cancer and others don't?
The chances of getting a disease are called risk factors and it's based on different things like the genes you inherit, the lifestyle you lead and the environment.
- Genetic risk factors- for example mutations in the BRCA1 gene can lead to breast cancer, these mutations may be inherited
- Mutations (changes to DNA) can be caused by chemicals or carcinogens. Some examples include smoke from cigarettes that can lead to lung cancer and drinking alcohol is a risk factor leading to liver cancer. These examples are lifestyle risk factors as a person has chosen to do these.
- Ionising radiation (UV light or X-rays) may cause skin cancers to form. This is an environmental factor as you can't escape the sunlight when outdoors! However, sunbathing would be a lifestyle factor, as a person would choose to sunbathe.
- Around 15% of cancers are caused by viral infections, for example, the human papilloma virus (HPV) can be spread through sexual intercourse. Teenagers in the UK are now vaccinated against HPV. This would be a lifestyle risk factor as the virus has spread through sexual intercourse.
In the following activity, you will discuss risk factors that may lead to cancer.